Does neural induction of adult stem cells in vitro make sense? Results of our poll

by Alexey Bersenev on September 24, 2013 · 0 comments

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A month ago, we’ve asked your opinion about neural induction of adult stem cells in vitro for clinical use. This is a very popular trend in cell therapy. But my brief investigation didn’t result in any reasonable explanation of benefits for such approach. I was thinking: “Why do we need to push cells in neuronal phenotype, if they can do the same job without such induction?” I’ve asked this question few experts from recent conferences that I’ve attended. All of them were not supportive the idea of neural induction in vitro. The results of this poll, recent publications and expert’s opinions solidify my position – there is no point to do it. Now, I’d like to share the results of our poll.

We got 22 replies. First, we asked if you believe that bone marrow or cord blood stem cells can be induced in functional mature neurons or glial cells in vitro?

neuronsinvitro

So, majority (59%) of you think that bone marrow stem cells or cord blood stem cell can not be induced in mature functional neurons in vitro. From those of you, who think that it’s not possible, 69% consider it as a cell culture artifact and 31% consider it as only a “transition to neuronal fate” (shifting gene expression).

Second, we asked if such neural induction make any sense in neurology clinic. Here the results:

clinicsense

So, most of you think, that there is no point to do it for clinical use.

You can look at original results of a poll here.

I think, this issue is important and should be discussed, because clinical trials have been started. You can look at 2 multiple sclerosis FDA approved trials in US – one is using neurally-induced MSC and another is using just MSC without any induction. Please feel free to discuss!

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