Because of high cost, supply limitations and safety issues, cell therapy developers have been looking for alternatives to animal serum in the last few years. There are two major directions for animal serum replacement in cell therapy:
- defined growth factors (“synthetic” serum replacement)
- natural human blood-derived products
I think, a great progress was made in both directions. Today, I’d like to focus on latter approach. Human-derived blood products have been validated recently in GMP-grade protocols. There are a number of comparative studies (human-derived products versus animal serum). I’ve picked few significant trends in development of animal serum replacement strategies.
Replacement of animal serum in cell therapy manufacturing:
4. Cord blood serum
So, I’m quite optimistic on this matter and I don’t think we will have a lot of problems with “peak serum“. What do you think?