Prospective isolation of human mesenchymal stem cells

by Alexey Bersenev on July 24, 2011 · 0 comments

in mesenchymal, reviews

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The recent review nicely summarizes the most frequently used markers for isolation of human mesenchymal stem cells (MSC) from different tissues.

Conventionally, MSC are functionally isolated by their capacity to adhere to the surface of culture plates. The resulting cells are poorly defined and give rise to a heterogeneous mixture of cells including MSC, reticular cells, macrophages, and endothelial cells. To gain information about the starting population, several markers have been introduced to prospectively isolate MSC and their subsets. A similar degree of hierarchy and progenitor cell heterogeneity may exist among MSC as described for the hematopoietic system. The identification of MSC subsets and clonal analysis of individual MSC may contribute to gain more insight in the heterogeneity of MSC from different tissues

Read special issue of Best Practice and Research Clinical Hematology dedicated to MSC and freely available.

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