Same day ex-vivo gene therapy – a novel strategy

by Alexey Bersenev on May 17, 2011 · 0 comments

in gene transfer

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A new strategy for ex vivo gene therapy was recently proposed in Molecular Therapy.

The purpose of this preclinical study was to compare the osteoinductive potential of a novel “same day” ex-vivo regional gene therapy versus a traditional two-step approach, which involves culture expansion of the donor cells before implantation. In the “same day” strategy buffy coat cells were harvested from the rat bone marrow, transduced with a lentiviral vector-expressing BMP-2 for 1 hour and implanted into a rat femoral defect in the same sitting.

The “same day” strategy represents a significant advance in the field of ex-vivo regional gene therapy because it offers a solution to limitations associated with the culture expansion process required in the traditional ex vivo approach. This strategy should be cost-effective when adapted for human use.

Very good approach and important conclusions!

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