Two-parts review about cell-based products in tissue engineering, published in Tissue Engineering Part B, available in open access.
The review is really huge and look like book chapter. The authors proposed new methodological approaches in tissue engineering based on understanding developmental biology and systems biology.
The field of tissue engineering is moving toward a new concept of â€œin vitro biomimetics of in vivo tissue development.â€ In Part I of this series, we proposed a theoretical framework integrating the concepts of developmental biology with those of process design to provide the rules for the design of biomimetic processes. We named this methodology â€œdevelopmental engineeringâ€ to emphasize that it is not the tissue but the process of in vitro tissue development that has to be engineered. To formulate the process design rules in a rigorous way that will allow a computational design, we should refer to mathematical methods to model the biological process taking place in vitro.
We will look into the applicability of systems biology and network science to the design of processes that are fully biomimetic, yet simple and robust enough to be practical, since in vivo developmental processes are by default robust. We attempt this using the concepts and terminology of these disciplines to position developmental engineering on a solid scientific foundation.