Lecture: Jeremy Rich – An evolving concept of cancer stem cells in tumor biology

by Alexey Bersenev on May 19, 2010 · 0 comments

in cancer, lectures

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Jeremy Rich – Professor, Chairman of the Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic. His recent work dedicated to targeting of glioblastoma stem cells.

This talk was recorder at the 101th annual meeting American Association of Cancer Research in April 17-21, 2010 and now available as a webcast.

(picture is clickable)

Some notes I took from his talk that I like:

    – 2 theories (clonal evolution and cancer stem cells) are not mutually exclusive and likely act concurrently;
    – cancer stem cell (CSC) are functionally definded by self-renewal, susteained proliferation and tumor initiation -propagation ability;
    – CSC act not in cell autonomous manner;
    – other proposed functional characteristics of CSC – invasion-metastasis, immune evasion, relationship to niche, angiogenesis;
    – cell lines fail to replicate original heterogeneity.

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