Minimal criteria for defining human multipotent mesenchymal stromal cells

by Alexey Bersenev on March 29, 2010 · 1 comment

in consensus, mesenchymal

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I’d like to share a document – Position statement of International Society for Cellular Therapy (ISCT) for defining multipotent mesenchymal stromal cells (MSC). This consensus report was written by 10 leading experts in the field of MSC research and was published in Cytotherapy journal in 2006.

The defining characteristics of MSC are inconsistent among investigators.
These varied tissue sources and methodologies of cell preparation beg the question of whether the resulting cells are sufficiently similar to allow for a direct comparison of reported biologic properties and experimental outcomes, especially in the context of cell therapy. This question of cell equivalence is, in part, because of the lack of universally accepted criteria to define MSC. Most importantly, the inability to compare and contrast studies from different groups is likely to hinder progress in the field.

To address this problem, the Mesenchymal and Tissue Stem Cell Committee of the ISCT proposes a set of standards to define human MSC for both laboratory-based scientific investigations and for pre-clinical studies. These identifying criteria should not be confused with release specifications for clinical studies, as the current proposal is intended solely as identifying criteria for research purposes.

You can find full report (.pdf) on ISCT web site.

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